I think it's a very realistic goal, and that guy covers exactly what I was suggesting, which is making sure your bracing is big enough, if you make a solid top with the access holes cut out like he suggests there should be plenty of meat to hold it together (as long as you don't go crazy with your access holes).

I would certainly practice your acrylic joining with some scrap pieces of 1/2" so you can make sure that you can glue long corner joints and such without bubbles or other imperfections that could cause it to fail.